Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface
نویسندگان
چکیده
منابع مشابه
Chondroitin sulfate concentration and protein-polysaccharide composition of articular cartilage in osteoarthritis.
In osteoarthritis the articular cartilage becomes roughened, fibrillar, softened, thinned, and finally eroded, with secondary changes occurring in the underlying bone. Histologically, early cartilage lesions in osteoarthritis are characterized by loss of metachromasia in the matrix, and it has been postulated that the initial disturbance involves the intercellular substance (1, 2). The decrease...
متن کاملCopolymers of chondroitin 4-sulfate and chondroitin 6-sulfate in chick embryo epiphyses and other cartilage.
Tetrasaccharides were prepared from chondroitin sulfate by means of a limited degradation with chondroitinase ABC. Tetrasaccharides containing one sulfate per disaccharide unit were isolated and were found to be of three types: a tetrasaccharide with two 6-sulfated disaccharide units, a tetrasaccharide with two 4-sulfated disaccharide units, and a tetrasaccharide with one 4-sulfated disaccharid...
متن کاملOn the structure of bovine articular cartilage high density proteoglycans. Isolation of the keratan sulfate and chondroitin sulfate side chains.
The structure of adult bovine articular cartilage high density proteoglycans (PG-I) was studied by degradation with Pronase, chondroitinase ABC, and alkaline borohydride treatments and fractionation and analysis of the products. The keratan sulfate (KS) peptides were rich in glutamic acid, proline, and serine and had a low glycine content. The chondroitin sulfate (CS) peptides had a high conten...
متن کاملGlyco-Forum section For intra-articular delivery of chondroitin sulfate
So far, there is no efficient treatment that could stop the pathological process of osteoarthritis (OA), and the management of the disease is mainly based on the alleviation of clinical symptoms by nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics compounds. However, some natural products have been proposed as symptomatic treatments, and named symptomatic slow acting disease modifyin...
متن کاملThe sulfation of chondroitin sulfate in embryonic chick cartilage epiphyses.
With the use of purified chondroitinase of Proteus vulgaris, a method has been devised for the determination of relative amounts of chondroitin, chondroitin-4-SO*, and chondroitin6-SO4 in cartilage. This method was applied to the analysis of embryonic chick epiphyseal cartilage. With 35S04 and ‘*C-acetate it was possible to study the relationship of embryo age to rate of formation of chondroiti...
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ژورنال
عنوان ژورنال: Current Research in Biotechnology
سال: 2020
ISSN: 2590-2628
DOI: 10.1016/j.crbiot.2020.02.002